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KMID : 0380620090410030320
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Korean Journal of Food Science and Technology
2009 Volume.41 No. 3 p.320 ~ p.325
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Acute Oral Toxicity and Anti-obesity Effect of Diglyceride PreparationContaining Conjugated Linoleic Acid in Rat
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Hong Soon-Gi
Park Chae-Kyu
Lee Mi-Ja
Chung Shin-Kyo
Lee Young-Ho
Hyun Sun-Hee
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Abstract
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The present study was carried out to investigate the acute oral toxicity and anti-obesity effects of a diglyceridepreparation containing conjugated linoleic acid (DG+CLA). To test its acute oral toxicity, the DG+CLA was injected into 30rats (15males and 15 females) at dosage of 2,000mg/kg and 5,000mg/kg. Mortality rates, clinical signs, and body weightchanges were monitored for 14 days following administration. According to the results, the lethal dose (LD50) of DG+CLAwas determined as >5,000mg/kg in both sexes. There were no significant changes in general conditions, clinical signs, bodyweight, and gross lesions between the vehicle control and DG+CLA groups. For the anti-obesity studies, obese Zucker ratswere randomly divided into 4 groups and fed saline, soybean oil, diglyceride, and DG+CLA, respectively, for 8 weeks. TheDG+CLA groups presented significant differences in body weight, food efficiency ratio, serum lipid levels, and fat weight.Overall, the results showed that the DG+CLA did not have acute oral toxicity and reduced body weight, serum lipid levels,and fat gain.
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KEYWORD
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diglyceride preparation containing conjugated linoleic acid, acute oral toxicity, anti-obesity, serum lipid levels, fat weight
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